Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives
نویسندگان
چکیده
منابع مشابه
Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives.
Hundred years ago therapeutic vaccination with allergen-containing extracts has been introduced as a clinically effective, disease-modifying, allergen-specific and long-lasting form of therapy for allergy, a hypersensitivity disease affecting more than 25% of the population. Today, the structures of most of the disease-causing allergens have been elucidated and recombinant hypoallergenic allerg...
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Background IgE-mediated allergy to peach represents a frequent cause of severe anaphylactic reactions in Mediterranean countries. Pru p 3, a nonspecific lipid transfer protein (LTP) from peach, was identified as an important elicitor of IgEmediated food hypersensitivity reactions to peach. Specific immunotherapy is currently the only allergen-specific and disease-modifying treatment of allergie...
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BACKGROUND Pollen extracts and chemically modified allergoids are used successfully in allergen immunotherapy (AIT). Recombinant extracts offer potential advantages with respect to pharmaceutical quality, standardization and dosing. A hypoallergenic recombinant folding variant of the major birch pollen allergen (rBet v 1-FV) was compared with an established native birch preparation. A pre-seaso...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2012
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2011.11.011